IL13Ralpha2-specific hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing autologous TN/MEM Cells

{
  "id": "MLC-T-ONC-014352",
  "term": "IL13Ralpha2-specific hinge-optimized 4-1BB-co-stimulatory CAR/Truncated CD19-expressing autologous TN/MEM Cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of ex vivo expanded, genetically modified autologous naïve and memory T cells (TN/MEM) transduced with a replication incompetent, self-inactivating (SIN) lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR) specific for interleukin-13 receptor alpha 2 (IL13Ra2), and containing the cluster of differentiation 137 (CD137; 4-1BB) co-stimulatory signaling domain fused to the signaling domain of the T-cell antigen receptor complex zeta chain (CD3-zeta), and a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating and antineoplastic activities. Upon intratumoral or intracavitary administration, IL13Ra2-specific hinge-optimized 4-1BB-co-stimulatory CAR/truncated CD19-expressing autologous TN/MEM cells are directed to, and induce selective toxicity and cytolysis in, IL13Ra2-expressing tumor cells. IL13Ra2, overexpressed by a variety of tumor cell types, is associated with increased proliferation, migration and invasiveness of tumor cells. The co-stimulatory signaling domain enhances both proliferation of T cells and antitumor activity. Hinge optimization prevents the recognition and clearance of the CAR by endogenous Fc receptors (FcRs). CD19t is used as a surface marker to both track and quantify the modified T cells in vivo.",
  "synonyms": [
    "IL13 [EQ]BBzeta/truncated CD19[t]+ naive and memory T cells",
    "IL13Ra2-specific-hinge-optimized-4-1BB-CAR/truncated CD19-expressing autologous TN/MEM lymphocytes",
    "IL13 [EQ]BBzeta/truncated CD19[t]+ TN/MEM cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/il13ralpha2-specific-hinge-optimized-4-1bb-co-stimulatory-car-truncated-cd19-tn/"
}