Autologous CD4- and CD8-positive truncated CD19-expressing antigen presenting T cells

{
  "id": "MLC-T-ONC-011559",
  "term": "Autologous CD4- and CD8-positive truncated CD19-expressing antigen presenting T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of ex vivo expanded, autologous CD4 and CD8 positive antigen presenting T cells (T-APCs), genetically modified with a transgene encoding a truncated form of human cluster of differentiation 19 (CD19t), with potential immunostimulating activity. Upon infusion, autologous CD19t-expressing T-APCs may stimulate the proliferation and activation of preadministered therapeutic CD19-targeted chimeric antigen receptor T cells (CAR-T). This may both improve the persistence of the therapeutic CAR-T cells and prevent relapse in patients with CD19 positive leukemia or lymphoma. CD19 is a B-cell specific cell surface antigen that is expressed in all B-cell lineage malignancies.",
  "synonyms": [
    "autologous CD19t T-APC",
    "autologous T-cell antigen presenting cells expressing truncated CD19",
    "autologous CD19t T-antigen presenting cells",
    "autologous T-cell antigen presenting cells expressing CD19t"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cd4-and-cd8-positive-truncated-cd19-expressing-antigen-presenting-t/"
}