idiotype-pulsed autologous dendritic cell vaccine APC8020

{
  "id": "MLC-T-ONC-014314",
  "term": "idiotype-pulsed autologous dendritic cell vaccine APC8020",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based cancer vaccine composed of autologous dendritic cells (DCs) pulsed with tumor-derived clonal immunoglobulin (Ig) with potential immunostimulatory and antineoplastic activities. Upon administration, idiotype-pulsed autologous dendritic cell vaccine APC8020, containing idiotype (Id) protein structures that can be recognized by antibodies and by CD41 T lymphocytes and CD81 T lymphocytes, may stimulate antitumoral cytotoxic T lymphocyte (CTL) and antibody responses against Id-expressing tumor cells. The Id represents the unique antigenic determinants in the variable regions of the clonal Ig.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/idiotype-pulsed-autologous-dendritic-cell-vaccine-apc8020/"
}