indoximod

{
  "id": "MLC-T-ONC-014445",
  "term": "indoximod",
  "field": "Oncology and biomedicine",
  "definition": "A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.",
  "abbreviation": "1-MT",
  "synonyms": [
    "1-methyl-d-tryptophan",
    "D-(+)-1-methyltryptophan",
    "D-1MT"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indoximod/"
}