anti-CD20 monoclonal antibody B001

{
  "id": "MLC-T-ONC-010289",
  "term": "anti-CD20 monoclonal antibody B001",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant humanized monoclonal antibody directed against human CD20 with potential antineoplastic activity. Upon intravenous administration, anti-CD20 monoclonal antibody B001 specifically binds to CD20 on the surfaces of B cells. Although the exact mechanisms through which B001 exert its effects have not been elucidated, B001 may induce a B-cell-directed cell-mediated immune response against CD20-expressing B cells and/or prevent CD20-medaited signaling. This induces tumor cell apoptosis and inhibits proliferation. CD20 is a non-glycosylated cell surface phosphoprotein which is exclusively expressed on B cells during most stages of B-cell development and which is often overexpressed in B-cell malignancies.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd20-monoclonal-antibody-b001/"
}