Alteplase

{
  "id": "MLC-T-ONC-000418",
  "term": "Alteplase",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent. Also called Activase, r-tPA, and recombinant tissue plasminogen activator.",
    "A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism."
  ],
  "abbreviation": "rt-PA",
  "synonyms": [
    "Activase",
    "r-tPA",
    "recombinant tissue plasminogen activator",
    "t-PA",
    "plasminogen activator (human tissue-type protein moiety)"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/alteplase/"
}