aminolevulinic acid hydrochloride

{
  "id": "MLC-T-ONC-000456",
  "term": "aminolevulinic acid hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used under the brand names Ameluz and Levulan Kerastick with photodynamic therapy to treat actinic keratosis (a skin condition that may become cancer) and under the brand name Gleolan as an imaging agent during surgery for certain types of brain tumors. Aminolevulinic acid hydrochloride is also being studied in the treatment of other conditions and types of cancer. When aminolevulinic acid hydrochloride is taken up by abnormal cells, including cancer cells, and is then exposed to certain types of light, it becomes active and kills the cells. It may also help find some types of cancer cells when they are exposed to certain types of light. Aminolevulinic acid hydrochloride is a type of photosensitizing agent.",
    "The hydrochloride salt form of aminolevulinic acid, an aminoketone, used for local photosensitizing therapy. Aminolevulinic acid (ALA) is a metabolic pro-drug that is converted into the photosensitizer protoporphyrin IX (PpIX), which accumulates intracellularly. Upon exposure to light of appropriate wavelength (red, or blue), PpIX catalyzes oxygen to singlet oxygen, an intracellular toxin, which can further react to form superoxide and hydroxyl radicals. This leads to cellular cytotoxic effects."
  ],
  "synonyms": [
    "aminolevulinic acid HCl",
    "delta-aminolevulinic acid hydrochloride"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aminolevulinic-acid-hydrochloride/"
}