anti-AMHR2 monoclonal antibody GM102

{
  "id": "MLC-T-ONC-010121",
  "term": "anti-AMHR2 monoclonal antibody GM102",
  "field": "Oncology and biomedicine",
  "definition": "An engineered, humanized, low fucose monoclonal antibody against mullerian hormone receptor II (Müllerian Inhibiting Substance Receptor II; AMHR2; AMHRII), with potential antineoplastic activity. Upon administration, anti-AMHR2 monoclonal antibody GM102 targets, binds to and inhibits AMHR2 and its downstream signaling pathways. GM102 primarily induces antibody dependent cellular cytotoxicity (ADCC) directed against AMHR2-expressing tumor cells through binding to CD16 (Fc-gammaRIIIa) that is present on immune effector cells. Decreased antibody fucosylation increases its affinity for binding to CD16 and ultimately enhances ADCC. AMHR2 is expressed in a subset of gynecological cancers.",
  "synonyms": [
    "anti-AMHR2 monoclonal antibody GM10II",
    "GM102 antibody"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-amhr2-monoclonal-antibody-gm102/"
}