anti-CD24/anti-4-1BB bispecific monoclonal antibody IBD0333

{
  "id": "MLC-T-ONC-010320",
  "term": "anti-CD24/anti-4-1BB bispecific monoclonal antibody IBD0333",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific monoclonal antibody targeting the cell surface antigen cluster of differentiation 24 (CD24) and the costimulatory receptor 4-1BB (CD137; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD24/anti-4-1BB bispecific monoclonal antibody IBD0333 simultaneously targets and binds to CD24 expressed on the surface of tumor cells and 4-1BB expressed on a variety of leukocyte subsets including activated T lymphocytes. This crosslinks CD24-expressing tumor cells and 4-1BB-expressing T-cells, and activates 4-1BB signaling locally in the tumor microenvironment (TME). This results in cytotoxic T-cell co-stimulation, enhances T-lymphocyte-mediated anti-tumor activity and leads to cytotoxic T-cell-mediated lysis of CD24-expressing tumor cells. CD24, a glycophosphatidylinositol (GPI)-anchored, highly glycosylated cell adhesion protein, is overexpressed on the surface of a variety of cancer cells. Expression of CD24, and its interaction with Siglec-10, protects cancer cells from phagocytosis, thereby allowing cancer cells to proliferate. Its expression is correlated with poor prognosis. 4-1BB, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.",
  "synonyms": [
    "anti-CD24/4-1BB bispecific monoclonal antibody IBD0333",
    "anti-4-1BB/anti-CD24 bispecific monoclonal antibody IBD0333",
    "anti-CD24 x 4-1BB bispecific monoclonal antibody IBD0333",
    "4-1BB/CD24 bispecific antibody IBD0333",
    "anti-CD24/anti-CD137 bispecific antibody IBD0333"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-cd24-anti-4-1bb-bispecific-monoclonal-antibody-ibd0333/"
}