anti-claudin-1 monoclonal antibody ALE.C04

{
  "id": "MLC-T-ONC-010488",
  "term": "anti-claudin-1 monoclonal antibody ALE.C04",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the tumor-associated antigen (TAA) claudin-1 (CLDN1; CLDN-1), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CLDN1 monoclonal antibody ALE.C04 targets and binds to a specific extracellular loop epitope that is exposed in non-junctional (NJ) CLDN1 expressed on certain tumor cells. This prevents CLDN1-mediated signaling, which disrupts the stiff extracellular matrix (ECM) in tumors and, by disturbing the physical barrier, enhances the infiltration of immune cells, such as natural killer cells (NKs) and T cells. This abrogates immunosuppression in the tumor microenvironment (TME) and leads to NK- and T-cell-mediated tumor cell killing. In addition, ALE.C04 can directly kill CLDN1-expressing tumor cells via antibody-dependent cell mediated cytotoxicity (ADCC). CLDN1, which is normally confined within the tight junctions in epithelial tissues, is overexpressed on a variety of tumor cells in a non-junctional form. CLDN1 overexpression on tumor cells correlates with ECM remodeling and T-cell exclusion, and is associated with reduced efficacy of checkpoint inhibitors (CPIs).",
  "synonyms": [
    "anti-claudin 1 monoclonal antibody ALE.C04",
    "anti-CLDN1 monoclonal antibody ALE.C04"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-claudin-1-monoclonal-antibody-ale-c04/"
}