anti-EGFR/HER3 monoclonal antibody MEHD7945A

{
  "id": "MLC-T-ONC-010612",
  "term": "anti-EGFR/HER3 monoclonal antibody MEHD7945A",
  "field": "Oncology and biomedicine",
  "definition": "An immunoglobulin (Ig) G1 monoclonal antibody directed against both human epidermal growth factor receptor 3 (HER3 or ERBB3) and human epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Anti-EGFR/HER3 Monoclonal Antibody MEHD7945A binds to both EGFR and HER3 and inhibits their activation. This may prevent EGFR/HER3-mediated signaling and inhibit EGFR/HER3-dependent tumor cell proliferation. In addition, MEHD7945A induces antibody-dependent cell-mediated cytotoxicity (ADCC) against EGR/HER3-expressing tumor cells. EGFR and HER3, members of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, are frequently overexpressed in tumors; their expression is associated with both poor prognosis and drug resistance.",
  "synonyms": [
    "anti-erbB1/erbB3 monoclonal antibody MEHD7945A"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-egfr-her3-monoclonal-antibody-mehd7945a/"
}