anti-GFRAL monoclonal antibody NGM120

{
  "id": "MLC-T-ONC-010700",
  "term": "anti-GFRAL monoclonal antibody NGM120",
  "field": "Oncology and biomedicine",
  "definition": "A long-acting monoclonal antibody directed against glial-cell-derived neurotrophic factor (GDNF) family receptor alpha-like (GFRAL), with potential anti-anorexia and anti-cachexia activities. Upon administration, NGM120 targets, binds to and blocks GFRAL. This prevents binding of growth differentiation factor 15 (GDF15; MIC-1) to its receptor GFRAL and prevents GDF15/GFRAL-mediated signaling. This may abrogate loss of appetite and uncontrolled weight loss associated with high serum levels of GDF15. GDF15, a stress response cytokine and divergent member of the TGF-beta superfamily, plays a key role in the regulation of body weight through central mechanisms. High GDF15 plasma levels, as seen in individuals with advanced cancers, are associated with loss of body mass.",
  "synonyms": [
    "GFRAL antagonistic monoclonal antibody NGM120"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gfral-monoclonal-antibody-ngm120/"
}