anti-gremlin-1 monoclonal antibody UCB6114

{
  "id": "MLC-T-ONC-010723",
  "term": "anti-gremlin-1 monoclonal antibody UCB6114",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against gremlin-1 (GREM1; Drm), with potential antineoplastic activity. Upon administration, anti-gremlin-1 antibody UCB6114 specifically targets and binds to gremlin-1, thereby neutralizing Gremlin-1. This may block the gremlin-1-mediated inhibition of bone morphogenetic protein (BMP) signaling pathways, and may lead to the inhibition of tumor cell growth and proliferation. Gremlin-1, a BMP antagonist that is overexpressed in a variety of cancer cell types, is involved in cancer cell growth and proliferation as well as tissue fibrosis.",
  "synonyms": [
    "anti-GREM1 antibody monoclonal UCB6114"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gremlin-1-monoclonal-antibody-ucb6114/"
}