anti-HER2/anti-PD-1 bispecific antibody SSGJ-705

{
  "id": "MLC-T-ONC-010758",
  "term": "anti-HER2/anti-PD-1 bispecific antibody SSGJ-705",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against the human epidermal growth factor receptor 2 (HER2; EGFR2, ERBB2) and the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-HER2/anti-PD-1 bispecific antibody SSGJ-705 simultaneously targets, binds to and inhibits HER2 and PD-1 and their downstream signaling pathways, and bridges PD-1-expressing T cells to HER2-expressing tumor cells. This may inhibit tumor cell proliferation of HER2-overexpressing cells. Inhibition of PD-1-mediated signaling may restore immune function through the activation of T cells and T-cell-mediated immune responses against the HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands programmed cell death-1 ligand 1 (PD-L1) or 2 (PD-L2); it plays an important role in tumor evasion from host immunity.",
  "synonyms": [
    "anti-HER2/PD-1 bispecific antibody SSGJ-705",
    "HER2 x PD-1 bispecific antibody SSGJ-705"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her2-anti-pd-1-bispecific-antibody-ssgj-705/"
}