anti-HER2-DM1 ADC B003

{
  "id": "MLC-T-ONC-010765",
  "term": "anti-HER2-DM1 ADC B003",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) consisting of a recombinant humanized anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC), with potential antineoplastic activity. Upon administration of B003, the anti-HER2 monoclonal antibody moiety targets and binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics, inhibiting cell division and the proliferation of cancer cells that overexpress HER2.",
  "synonyms": [
    "anti-HER2-DM1 antibody-drug conjugate B003",
    "recombinant humanized anti-HER2 monoclonal antibody-MCC-DM1 B003",
    "ADC B003"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her2-dm1-adc-b003/"
}