anti-LAG3 monoclonal antibody TSR-033

{
  "id": "MLC-T-ONC-010849",
  "term": "anti-LAG3 monoclonal antibody TSR-033",
  "field": "Oncology and biomedicine",
  "definition": "A humanized, immunoglobulin G4 (IgG4) monoclonal antibody directed against the inhibitory receptor lymphocyte activation gene 3 protein (LAG3; LAG-3), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, the anti-LAG3 monoclonal antibody TSR-033 binds to LAG3 expressed on tumor-infiltrating lymphocytes (TILs) and blocks its binding with major histocompatibility complex (MHC) class II molecules expressed on tumor cells. This activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which leads to a reduction in tumor growth. LAG3, a member of the immunoglobulin superfamily (IgSF), is expressed on various immune cells, and negatively regulates both proliferation and activation of T-cells. Its expression on TILs is associated with tumor-mediated immune suppression.",
  "synonyms": [
    "anti-lymphocyte activation gene 3 protein monoclonal antibody TSR-033",
    "anti-LAG-3 monoclonal antibody TSR-033"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-lag3-monoclonal-antibody-tsr-033/"
}