anti-LAIR1 monoclonal antibody NGM438

{
  "id": "MLC-T-ONC-010855",
  "term": "anti-LAIR1 monoclonal antibody NGM438",
  "field": "Oncology and biomedicine",
  "definition": "A monoclonal antibody directed against the collagen-binding immune inhibitory receptor leukocyte-associated immunoglobulin-like receptor 1 (LAIR1; LAIR-1; CD305), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, anti-LAIR1 monoclonal antibody NGM438 targets, binds to and blocks LAIR1, thereby preventing its interaction with tumor-associated and stromal-derived collagens and the formation of the stromal checkpoint LAIR1-collagen complex. This may inhibit LAIR1-collagen complex-mediated downstream signaling pathways and abrogates LAIR1-collagen complex-mediated myeloid cell immune suppression and inhibition of antitumor immunity. This may also inhibit the physical exclusion of immune cells from the tumor by the LAIR1-collagen complex and enhance T-cell infiltration of the tumor. LAIR1, an immune inhibitory receptor expressed on immune cells and upregulated in various cancers along with stromal-derived collagens, plays an important role in tumor infiltration, immunosuppression and immune tolerance.",
  "synonyms": [
    "anti-LAIR1 antagonist antibody NGM438"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-lair1-monoclonal-antibody-ngm438/"
}