anti-PD-1/anti-VEGF bispecific antibody AI-081

{
  "id": "MLC-T-ONC-010983",
  "term": "anti-PD-1/anti-VEGF bispecific antibody AI-081",
  "field": "Oncology and biomedicine",
  "definition": "A Fc-silenced, bispecific antibody directed against the negative immunoregulatory human cell receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and the human vascular endothelial growth factor (VEGF), with potential immune checkpoint inhibitory, anti-angiogenic and antineoplastic activities. Upon administration, anti-PD-1/anti-VEGF bispecific antibody AI-081 simultaneously targets and binds to both PD-1 expressed on T cells and VEGF expressed on tumor cells. The binding of AI-081 to PD-1 prevents the activation of PD-1 by its ligands, programmed cell death-1 ligand 1 (PD-L1; CD274) and/or 2 (PD-L2; CD273). This abrogates T-cell inhibition, activates antigen-specific T lymphocytes and enhances cytotoxic T-lymphocyte (CTL)-mediated tumor cell lysis, which may lead to a reduction in tumor growth. The binding of AI-081 to VEGF prevents binding of VEGF to its receptor VEGFR, abrogates VEGF/VEGFR-mediated signaling and may lead to the inhibition of vascular endothelial cell proliferation. The inhibition of tumor angiogenesis may further decrease tumor cell proliferation and prevent metastasis. PD-1, a transmembrane protein in the immunoglobulin superfamily (IgSF) expressed on T cells, functions as an immune checkpoint that negatively regulates T-cell activation and effector function when activated by its ligands PD-L1 and/or PD-L2; it plays an important role in tumor evasion from host immunity. VEGF is overexpressed in a variety of cancers and is associated with increased invasiveness and decreased survival.",
  "synonyms": [
    "anti-PD-1/VEGF bispecific antibody AI-081",
    "anti-VEGF/anti-PD-1 bispecific antibody AI-081",
    "PD-1 x VEGF bispecific antibody AI-081"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-pd-1-anti-vegf-bispecific-antibody-ai-081/"
}