anti-PDGFR alpha monoclonal antibody MEDI-575

{
  "id": "MLC-T-ONC-010996",
  "term": "anti-PDGFR alpha monoclonal antibody MEDI-575",
  "field": "Oncology and biomedicine",
  "definition": "A humanized monoclonal antibody directed against the platelet-derived growth factor receptor (PDGFR) alpha with potential antineoplastic activity. Anti-PDGFR alpha monoclonal antibody MEDI-575 inhibits activation of the cell-surface tyrosine kinase PDGFR alpha subunit and subsequent triggering of mitogenic signaling pathways, including the JAK/STAT, PI3K/Akt, and MAP kinase pathways. PDGFR alpha acts as a mitogenic signaling receptor for cells of mesenchymal origin and inhibition of receptor activity may inhibit tumor cell proliferation.",
  "synonyms": [
    "anti-platelet-derived growth factor receptor alpha monoclonal antibody MEDI-575"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-pdgfr-alpha-monoclonal-antibody-medi-575/"
}