anti-RNF43 antibody-drug conjugate SC-006

{
  "id": "MLC-T-ONC-011071",
  "term": "anti-RNF43 antibody-drug conjugate SC-006",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the tumor-associated antigen (TAA) ring finger protein 43 (RNF43), linked to a DNA crosslinking pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of anti-RNF43 ADC SC-006 targets and binds to RNF43 expressed on tumor cells. Upon binding and internalization, the cytotoxic PBD moiety is released and forms highly cytotoxic DNA interstrand cross-links, thereby blocking cell division and killing RNF43-expressing cancer cells. RNF43, a single-span transmembrane E3 ubiquitin ligase, is overexpressed by certain tumor cell types and a negative regulator of the Wnt signaling pathway.",
  "synonyms": [
    "ADC SC-006",
    "anti-RNF43 ADC SC-006"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-rnf43-antibody-drug-conjugate-sc-006/"
}