anti-SEZ6 antibody-drug conjugate ABBV-706

{
  "id": "MLC-T-ONC-011088",
  "term": "anti-SEZ6 antibody-drug conjugate ABBV-706",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against seizure protein 6 homolog (SEZ6) linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration of anti-SEZ6 ADC ABBV-706, the monoclonal antibody moiety targets and binds to SEZ6 expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills SEZ6-expressing tumor cells through an as of yet undisclosed mechanism. SEZ6, overexpressed in certain cancers while minimally expressed in normal tissues, may play a role in cell-cell recognition and in neuronal membrane signaling.",
  "synonyms": [
    "anti-SEZ6 ADC ABBV-706"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-sez6-antibody-drug-conjugate-abbv-706/"
}