anti-SIRP monoclonal antibody ELA026

{
  "id": "MLC-T-ONC-011090",
  "term": "anti-SIRP monoclonal antibody ELA026",
  "field": "Oncology and biomedicine",
  "definition": "A human immunoglobulin G1 (IgG1) monoclonal antibody targeting certain specific proteins of the human signal-regulatory protein (SIRP) family, with potential immunoregulatory activity. Upon administration, anti-SIRP monoclonal antibody ELA026 targets and binds to SIRP, a cell surface protein expressed on myeloids and T lymphocytes. This depletes pathological myeloids and T lymphocytes that are circulating due to excessive immune activation and inflammation. This eradicates pathological immune cells that are driving inflammation. SIRP is a family of cell surface receptors expressed on various immune cell types. ELA026 does not inhibit the activity of the SIRPalpha/CD47 immune checkpoint.",
  "synonyms": [
    "SIRP-directed monoclonal antibody ELA026"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-sirp-monoclonal-antibody-ela026/"
}