anti-TROP2 antibody-drug conjugate BAT8008

{
  "id": "MLC-T-ONC-011152",
  "term": "anti-TROP2 antibody-drug conjugate BAT8008",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) conjugated via a cleavable linker to the camptothecin analog exatecan, with potential antineoplastic activity. Upon administration of the anti-TROP2 ADC BAT8008, the anti-TROP2 antibody targets and binds to TROP2 expressed on tumor cells. Upon binding, internalization and linker cleavage, exatecan is released. Exatecan inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation of TROP2-expressing tumor cells. TROP2 is a transmembrane protein overexpressed in various tumors. Its expression is associated with enhanced tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.",
  "synonyms": [
    "anti-TROP2 ADC BAT8008",
    "anti-TROP2/exatecan ADC BAT8008"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-trop2-antibody-drug-conjugate-bat8008/"
}