Arsenic trioxide

{
  "id": "MLC-T-ONC-000726",
  "term": "Arsenic trioxide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A drug used to treat acute promyelocytic leukemia that has a certain chromosome abnormality or a fusion gene called PML::RARA. It is used with tretinoin in some newly diagnosed adults. It is also used alone in patients whose cancer has not gotten better or has come back after treatment with other anticancer drugs. Arsenic trioxide is also being studied in the treatment of other types of cancer. Arsenic trioxide damages a fusion protein made by the PML::RARA fusion gene. This may help keep cancer cells from growing and may kill them. Also called Trisenox.",
    "A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic."
  ],
  "abbreviation": "ATO",
  "synonyms": [
    "Trisenox",
    "arsenic (III) oxide",
    "arsenic sesquioxide",
    "arsenous acid anhydride",
    "arsenous acid",
    "arsenous oxide",
    "white arsenic"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/arsenic-trioxide/"
}