Aryl hydrocarbon receptor antagonist BAY2416964

{
  "id": "MLC-T-ONC-011242",
  "term": "Aryl hydrocarbon receptor antagonist BAY2416964",
  "field": "Oncology and biomedicine",
  "definition": "An orally available formulation containing a small molecule antagonist of the aryl hydrocarbon receptor (AhR; class E basic helix-loop-helix protein 76; bHLHe76) with potential immunomodulating and antineoplastic activities. Upon oral administration, AhR antagonist BAY2416964 specifically binds to AhR, inhibits AhR activation, and prevents AhR-mediated signaling. Abrogation of AhR activation prevents the activation of immune-tolerant dendritic cells (DCs) and regulatory T cells (Tregs) in the tumor microenvironment (TME). This may restore the immune response against tumor cells. AhR, a member of the basic helix-loop-helix/Per-Arnt-Sim (bHLH/PAS) family of transcription factors, has important roles in regulating immunity and cellular differentiation. AhR can exhibit both pro-oncogenic and tumor suppressor-like functions depending on the tumor type; therefore, its expression may serve as a negative or positive prognostic factor.",
  "synonyms": [
    "AhR antagonist BAY2416964",
    "aryl hydrocarbon receptor inhibitor BAY2416964",
    "AhR inhibitor BAY2416964"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/aryl-hydrocarbon-receptor-antagonist-bay2416964/"
}