arzoxifene hydrochloride

{
  "id": "MLC-T-ONC-000739",
  "term": "arzoxifene hydrochloride",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of osteoporosis and breast cancer. Arzoxifene hydrochloride is made in the laboratory and binds to estrogen receptors in the body. It is a type of selective estrogen receptor modulator (SERM). Also called LY353381 hydrochloride.",
    "The hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. In comparison to other selective estrogen receptor modulators (SERMs), arzoxifene exhibits greater bioavailability and higher anti-estrogenic potency in the breast than raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene. This agent may have beneficial effects on bone and the cardiovascular system."
  ],
  "synonyms": [
    "LY353381 hydrochloride",
    "arzoxifenehydrochloride",
    "SERM-3",
    "SERM3",
    "LY353381 Hydrochloride"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/arzoxifene-hydrochloride/"
}