autologous c-Met/PD-L1-specific CAR T cells

{
  "id": "MLC-T-ONC-011574",
  "term": "autologous c-Met/PD-L1-specific CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been transduced with a lentiviral vector encoding a chimeric antigen receptor (CAR) specific for human hepatocyte growth factor receptor (HGFR or c-Met) and the immunosuppressive ligand, programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), with potential antineoplastic activities. Upon infusion, the autologous c-Met/PD-L1-specific CAR T cells bind to and induce selective toxicity in c-Met- and PD-L1-expressing tumor cells. cMET, a receptor tyrosine kinase that is overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis. PD-L1 is also overexpressed by many human cancer cell types and plays a key role in the downregulation of the immune system and tumor evasion from host immunity.",
  "synonyms": [
    "autologous anti-c-Met/PD-L1 CAR T cells",
    "autologous c-Met/PD-L1-specific CAR T lymphocytes"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-c-met-pd-l1-specific-car-t-cells/"
}