autologous HIV Gag-specific CD4+ T cells AGT103-T

{
  "id": "MLC-T-ONC-011647",
  "term": "autologous HIV Gag-specific CD4+ T cells AGT103-T",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, human immunodeficiency virus (HIV) Gag-specific, cluster of differentiation 4 (CD4)-positive T lymphocytes, with potential antiviral activity. Autologous HIV Gag-specific CD4+ T cells AGT103-T are prepared via ex vivo stimulation of autologous peripheral blood mononuclear cells (PBMCs) with Gag peptides, and the Gag-specific CD4+ T cells are transduced with the recombinant lentiviral vector AGT103 encoding inhibitory RNA targeting the HIV coreceptor C-C chemokine receptor type 5 (CCR5) and HIV sequences within the Vif/Tat coding regions. Upon administration, autologous HIV Gag-specific CD4+ T cells AGT103-T may prevent infection by CCR5- or CXCR4-tropic strains of HIV, reduce the depletion of CD4+ T cells upon HIV exposure and prevent latently-infected cells from releasing new HIV particles.",
  "synonyms": [
    "autologous HIV Gag-specific CD4-positive T lymphocytes AGT103-T",
    "autologous HIV-specific CD4 T cells AGT103-T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-hiv-gag-specific-cd4-plus-t-cells-agt103-t/"
}