B7-DC cross-linking antibody rHIgM12B7

{
  "id": "MLC-T-ONC-011859",
  "term": "B7-DC cross-linking antibody rHIgM12B7",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant form of the monoclonal IgM antibody M12 isolated from a Waldenstrom macroglobulinaemia patient (rHIgM12) with potential immunomodulating activity. B7-DC cross-linking antibody rHIgM12B7 binds and crosslinks the B7 co-stimulatory family member B7-DC (PD-L2) on dendritic cells (DCs), antigen presenting cells (APCs) that play a crucial role in the human immune response. This results in enhanced activation of DCs; enhanced antigen-presenting activity; and increased production of immunomodulatory cytokines (especially interleukin 12); and may potentiate a specific cytotoxic T lymphocyte (CTL) response against Waldenstrom macroglobulinaemia B cells.",
  "abbreviation": "rHIgM12B7",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/b7-dc-cross-linking-antibody-rhigm12b7/"
}