B7H3/CD3-targeting T-cell engaging molecule TAK-280

{
  "id": "MLC-T-ONC-011860",
  "term": "B7H3/CD3-targeting T-cell engaging molecule TAK-280",
  "field": "Oncology and biomedicine",
  "definition": "A T-cell engaging bispecific antibody and Conditional Bispecific Redirected Activation (COBRA) protein targeting both the tumor-associated antigen (TAA) and immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon intravenous administration, B7H3/CD3-targeting T-cell engaging molecule TAK-280 is cleaved by proteases in the tumor microenvironment (TME). Upon cleavage, TAK-280 is activated and binds to both CD3 on cytotoxic T lymphocytes (CTLs) and B7H3 on B7H3-expressing tumor cells. This activates and redirects CTLs to B7H3-expressing tumor cells, leading to a CTL-mediated killing of B7H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.",
  "synonyms": [
    "B7H3 x CD3 conditional bispecific redirected activation protein TAK-280",
    "B7H3 x CD3 T-BsAb TAK-280",
    "B7H3/CD3-engaging conditionally active bispecific antibody TAK-280",
    "COBRA protein TAK-280",
    "conditionally active T-cell engager TAK-280"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/b7h3-cd3-targeting-t-cell-engaging-molecule-tak-280/"
}