dual-affinity B7-H3/CD3-targeted protein MGD009

{
  "id": "MLC-T-ONC-013179",
  "term": "dual-affinity B7-H3/CD3-targeted protein MGD009",
  "field": "Oncology and biomedicine",
  "definition": "An Fc-bearing humanized bispecific dual-affinity re-targeting (DART) protein composed of Fv regions derived from monoclonal antibodies against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration of the MGD009 DART protein, the anti-B7-H3 component targets and binds to the cell surface antigen B7-H3; at the same time, the anti-CD3 component binds to human CD3. This cross-links the T cells to B7-H3-expressing tumor cells, activates and redirects endogenous T cells to kill B7-H3-expressing tumor cells, and inhibits proliferation of B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells but is minimally expressed by normal human tissues. B7-H3 is a negative regulator of T-cell activation and its overexpression plays a key role in immuno-evasion, tumor cell invasion and metastasis, and its expression is correlated with poor prognosis.",
  "synonyms": [
    "B7-H3 x CD3 dual-affinity re-targeting protein MGD009",
    "DART protein MGD009",
    "B7-H3 x CD3 DART protein"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dual-affinity-b7-h3-cd3-targeted-protein-mgd009/"
}