autologous anti-B7-H3 CAR T cells CAR.B7-H3T

{
  "id": "MLC-T-ONC-011328",
  "term": "autologous anti-B7-H3 CAR T cells CAR.B7-H3T",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous T lymphocytes that have been genetically engineered to express a chimeric antigen receptor (CAR) targeting the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and containing, as of yet undisclosed co-stimulatory signaling domains, with potential immunostimulating and antineoplastic activities. Upon infusion back into the patient, autologous anti-B7-H3 CAR T cells CAR.B7-H3T target and bind to B7-H3-expressing tumor cells, thereby inducing selective toxicity in B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.",
  "synonyms": [
    "CAR.B7-H3 T cells",
    "autologous anti-CD276 CAR T cells CAR.B7-H3T"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-anti-b7-h3-car-t-cells-car-b7-h3t/"
}