anti-B7-H3/CD28 bispecific antibody XmAb808

{
  "id": "MLC-T-ONC-010140",
  "term": "anti-B7-H3/CD28 bispecific antibody XmAb808",
  "field": "Oncology and biomedicine",
  "definition": "A bispecific antibody directed against the tumor-associated antigen (TAA) and immunoregulatory protein B7-homologue 3 (B7-H3, CD276) and the co-stimulatory T-cell surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration of anti-B7-H3/CD28 bispecific antibody XmAb808, this bispecific antibody binds to both B7-H3 on certain tumor cells and CD28 on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to B7-H3-expressing tumor cells, which may result in the CTL-mediated cell death of B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.",
  "synonyms": [
    "anti-B7-H3/anti-CD28 bispecific antibody XmAb808",
    "B7-H3 x CD28 bispecific antibody XmAb808"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-b7-h3-cd28-bispecific-antibody-xmab808/"
}