Bcl-2 inhibitor BCL201

{
  "id": "MLC-T-ONC-011899",
  "term": "Bcl-2 inhibitor BCL201",
  "field": "Oncology and biomedicine",
  "definition": "A selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2 inhibitor BCL201 binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 protein is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival.",
  "synonyms": [
    "Servier 1",
    "Servier-1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bcl-2-inhibitor-bcl201/"
}