BCL-2 inhibitor ICP-248

{
  "id": "MLC-T-ONC-011901",
  "term": "BCL-2 inhibitor ICP-248",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, Bcl-2 inhibitor ICP-248 targets, binds to and inhibits the activity of Bcl-2. This restores caspase-mediated apoptosis in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis. Its expression is associated with increased drug resistance and tumor cell survival.",
  "synonyms": [
    "BCL2 inhibitor ICP-248"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/bcl-2-inhibitor-icp-248/"
}