belzupacap sarotalocan

{
  "id": "MLC-T-ONC-011945",
  "term": "belzupacap sarotalocan",
  "field": "Oncology and biomedicine",
  "definition": "A formulation composed of nanoparticles derived from the human papillomavirus (HPV-NPs) and conjugated to the infrared (IR)-activated fluorescent dye IR700 (IR-700), with potential antineoplastic activity. Upon intravitreal injection of belzupacap sarotalocan, the HPV-NPs target and bind to heparan-sulfated proteoglycans (HSPG) expressed by ocular melanoma cells. Upon irradiation with near-IR (NIR) light, the photosensitizer IR700 becomes activated, generates reactive oxygen species (ROS) and selectively damages the melanoma cell membrane, which induces necrosis of the melanoma cells while sparing the surrounding, healthy non-HSPG-expressing tissue, and potentially preserving vision. HSPGs are overexpressed on a variety of cancer cell types.",
  "synonyms": [
    "VNC AU-011",
    "HPV-NP AU-011",
    "light-activated AU-011",
    "viral nanoparticle conjugates AU-011",
    "human papillomavirus virus-like particles conjugated with IR700 Dye AU-011"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/belzupacap-sarotalocan/"
}