cetuximab sarotalocan sodium

{
  "id": "MLC-T-ONC-012534",
  "term": "cetuximab sarotalocan sodium",
  "field": "Oncology and biomedicine",
  "definition": "The sodium salt form of cetuximab sarotalocan, which consists of a chemical conjugate composed of the dye IR700 linked to cetuximab, a monoclonal antibody directed against the epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon injection of cetuximab sarotalocan sodium, the cetuximab moiety targets and binds to EGFR-expressing tumor cells, resulting in the internalization of the conjugate. Upon localized application of near-infrared (NIR) light, the IR700 dye becomes activated, disrupts the cell membrane and selectively kills the EGFR-expressing tumor cells. EGFR, a tyrosine kinase receptor, is overexpressed in a variety of cancers.",
  "synonyms": [
    "cetuximab sarotalocan",
    "Cet-IR700",
    "cetuximab-IR700 conjugate RM-1929"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cetuximab-sarotalocan-sodium/"
}