Benzoylphenylurea

{
  "id": "MLC-T-ONC-000994",
  "term": "Benzoylphenylurea",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the treatment of cancer. It is a type of antitubulin agent. Also called BPU.",
    "A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function. This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle."
  ],
  "abbreviation": "BPU",
  "synonyms": [
    "BPU",
    "benzamide, N-(aminocarbonyl)-N-phenyl-"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/benzoylphenylurea/"
}