beta tubulin polymerization inhibitor CCI-001

{
  "id": "MLC-T-ONC-011974",
  "term": "beta tubulin polymerization inhibitor CCI-001",
  "field": "Oncology and biomedicine",
  "definition": "A colchicine derivative and beta tubulin polymerization inhibitor, with potential antineoplastic activity. Upon administration, beta tubulin polymerization inhibitor CCI-001 targets, binds to and inhibits beta-III tubulin (TUBB3), and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells. TUBB3, overexpressed in many cancers, is associated with poor outcomes and a reduced response to taxane-based microtubule-targeting antineoplastic agents.",
  "synonyms": [
    "colchicine derivative CCI-001"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/beta-tubulin-polymerization-inhibitor-cci-001/"
}