crolibulin

{
  "id": "MLC-T-ONC-012812",
  "term": "crolibulin",
  "field": "Oncology and biomedicine",
  "definition": "A small molecule tubulin polymerization inhibitor with potential antineoplastic activity. Microtubulin inhibitor EPC2407 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of tubulin into microtubules, which may result in cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. As a vascular disruption agent (VDA), this agent also disrupts tumor neovascularization, which may result in a reduction in tumor blood flow and tumor hypoxia and ischemic necrosis.",
  "synonyms": [
    "microtubulin inhibitor EPC2407",
    "microtubule inhibitor EPC2407"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/crolibulin/"
}