Microtubule-targeted agent BAL101553

{
  "id": "MLC-T-ONC-015175",
  "term": "Microtubule-targeted agent BAL101553",
  "field": "Oncology and biomedicine",
  "definition": "An orally available, highly water-soluble lysine prodrug of the synthetic small molecule BAL27862 with potential antitumor activity. Upon administration of BAL101553 and conversion into the active form BAL27862, this agent binds to tubulin at a site distinct from the vinca-alkaloid-binding site, and prevents tubulin polymerization and destabilizes microtubules, ultimately leading to cell cycle arrest, blockage of cell division and an induction of cell death in cancer cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/microtubule-targeted-agent-bal101553/"
}