ABT-751

{
  "id": "MLC-T-ONC-000119",
  "term": "ABT-751",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called sulfonamides.",
    "An orally bioavailable antimitotic sulfonamide. ABT-751 binds to the colchicine-binding site on beta-tubulin and inhibits the polymerization of microtubules, thereby preventing tumor cell replication. This agent also disrupts tumor neovascularization, reducing tumor blood flow and so inducing a cytotoxic effect."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/abt-751/"
}