biricodar dicitrate

{
  "id": "MLC-T-ONC-012022",
  "term": "biricodar dicitrate",
  "field": "Oncology and biomedicine",
  "definition": "The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents.",
  "synonyms": [
    "Incel VX-710"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/biricodar-dicitrate/"
}