P-glycoprotein inhibitor HM30181AK

{
  "id": "MLC-T-ONC-016000",
  "term": "P-glycoprotein inhibitor HM30181AK",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter P-glycoprotein (P-gp), with adjuvant activity. Upon oral administration, P-gp inhibitor HM30181AK selectively binds to and inhibits the multidrug resistance (MDR) efflux pump P-gp, which prevents the efflux of various chemotherapeutic agents from intestinal epithelial cells to the gastrointestinal tract. This leads to an increase in both oral bioavailability and therapeutic efficacy. P-gp prevents the intestinal uptake and intracellular accumulation of various cytotoxic agents. HM30181AK is not systemically absorbed.",
  "synonyms": [
    "Pgp inhibitor HM30181AK"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/p-glycoprotein-inhibitor-hm30181ak/"
}