thalicarpine

{
  "id": "MLC-T-ONC-017107",
  "term": "thalicarpine",
  "field": "Oncology and biomedicine",
  "definition": "A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle.",
  "synonyms": [
    "taliblastine",
    "thaliblastine",
    "thalicarpin"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/thalicarpine/"
}