MDR modulator CBT-1

{
  "id": "MLC-T-ONC-005173",
  "term": "MDR modulator CBT-1",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance taken from plants that is being studied in the treatment of cancer. It may help drugs kill tumor cells that have become resistant to drugs. It is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist. Also called CBT-1.",
    "A naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors."
  ],
  "synonyms": [
    "CBT-1"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mdr-modulator-cbt-1/"
}