MDM2/MDMX inhibitor ALRN-6924

{
  "id": "MLC-T-ONC-015045",
  "term": "MDM2/MDMX inhibitor ALRN-6924",
  "field": "Oncology and biomedicine",
  "definition": "An orally available inhibitor of both murine double minute 2 (MDM2) and murine double minute X (MDMX), with potential antineoplastic activity. Upon oral administration, ALRN-6924 binds to both MDM2 and MDMX and interferes with their interaction with the transcriptional activation domain of the tumor suppressor protein p53. By preventing MDM2-p53 and MDMX-p53 interactions, p53 activity is restored, which leads to p53-mediated induction of tumor cell apoptosis. MDM2 and MDMX, negative regulators of p53 function, are often overexpressed in cancer cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mdm2-mdmx-inhibitor-alrn-6924/"
}