7-hydroxystaurosporine

{
  "id": "MLC-T-ONC-009559",
  "term": "7-hydroxystaurosporine",
  "field": "Oncology and biomedicine",
  "definition": "A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/7-hydroxystaurosporine/"
}