serine/threonine kinase inhibitor CBP501

{
  "id": "MLC-T-ONC-016692",
  "term": "serine/threonine kinase inhibitor CBP501",
  "field": "Oncology and biomedicine",
  "definition": "A peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.",
  "synonyms": [
    "Cdc25C Phosphatase (211-221)"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/serine-threonine-kinase-inhibitor-cbp501/"
}