serine/threonine kinase inhibitor XL418

{
  "id": "MLC-T-ONC-016693",
  "term": "serine/threonine kinase inhibitor XL418",
  "field": "Oncology and biomedicine",
  "definition": "A selective, orally active small molecule, targeting protein kinase B (PKB or AKT) and ribosomal protein S6 Kinase (p70S6K), with potential antineoplastic activity. XL418 inhibits the activities of PKB and p70S6K, both acting downstream of phosphoinosotide-3 kinase (PI3K). These kinases are often upregulated in a variety of cancers. Inhibition of PKB by this agent will induce apoptosis, while inhibition of p70S6K will result in the inhibition of translation within tumor cells.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/serine-threonine-kinase-inhibitor-xl418/"
}